Cardiac amyloidosis is caused by the buildup of clumps of abnormally folded protein (known as amyloid fibrils) in the heart muscle. This impairs its ability to function normally. Cardiac amyloidosis is a cause of heart failure many people don’t know about. Learn symptoms of this condition and when to seek care. Abstract cardiac amyloidosis (ca) can lead to progressive heart failure (hf) by depositing insoluble amyloid fibrils within the myocardial extracellular space, resulting in an infiltrative and …